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ИНТЕРНЕТ-МАГАЗИН

Телефон издательства

Лечебное дело
2021 / N 1

Ключевые внутриклеточные механизмы в патогенезе острого панкреатита
С.А. Пономарь, Б.В. Болдин

Список литературы

1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri IS, Gangarosa LM, Jensen ET, Lund JL, Pasricha S, Runge T, Schmidt M, Shaheen NJ, Sandler RS. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology 2015 Dec;149(7):1731-41.e3.
2. Wadhwa V, Patwardhan S, Gard SK, Jobanputra Y, Lopez R, Sanaka MR. Health care utilization and costs associated with acute pancreatitis. Pancreas 2017 Mar;46(3):410-5.
3. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nature Reviews. Gastroenterology & Hepatology 2019 Mar;16(3):175-84.
4. Krishna SG, Kamboj AK, Hart PA, Hinton A, Conwell DL. The changing epidemiology of acute pancreatitis hospitalizations: a decade of trends and the impact of chronic pancreatitis. Pancreas 2017 Apr;46(4):482-8.
5. Párniczky A, Kui B, Szentesi A, Balázs A, Szűcs A, Mosztbacher D, Czimmer J, Sarlós P, Bajor J, Gódi S, Vincze A, Illés A, Szabó I, Pár G, Takács T, Czakó L, Szepes Z, Rakonczay Z, Izbéki F, Gervain J, Halász A, Novák J, Crai S, Hritz I, Góg C, Sümegi J, Golovics P, Varga M, Bod B, Hamvas J, Varga-Müller M, Papp Z, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group. Prospective, multicentre, nationwide clinical data from 600 cases of acute pancreatitis. PLoS One 2016 Oct;11(10):e0165309.
6. Maléth J, Hegyi P. Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 2016 Aug;371(1700):20150425.
7. Krüger B, Albrecht E, Lerch MM. The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. The American Journal Pathology 2000 Jul;157(1):43-50.
8. Raraty M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, Petersen OH. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the USA 2000 Nov;97(24):13126-31.
9. Criddle DN, McLaughlin E, Murphy JA, Petersen OH, Sutton R. The pancreas misled: signals to pancreatitis. Pancreatology 2007;7(5-6):436-46.
10. Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 2005 Oct;437(7060):902-5.
11. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J, Begg M, Stauderman K, Roos J, Grigoryev S, Ramos S, Rogers E, Whitten J, Velicelebi G, Dunn M, Tepikin AV, Criddle DN, Sutton R. Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models. Gastroenterology 2015 Aug;149(2):481-92.e7.
12. Gukovskaya AS, Pandol SJ, Gukovsky I. New insights into the pathways initiating and driving pancreatitis. Current Opinion in Gastroenterology 2016 Sep;32(5):429-35.
13. Lur G, Sherwood MW, Ebisui E, Haynes L, Feske S, Sutton R, Burgoyne RD, Mikoshiba K, Petersen OH, Tepikin AV. InsP(3)receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. The Biochemical Journal 2011 Jun;436(2):231-9.
14. Romac JMJ, Shahid RA, Swain SM, Vigna SR, Liddle RA. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nature Communications 2018 Apr;9(1):1715.
15. Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R; NIHR Pancreas Biomedical Research Unit. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut 2016 Aug;65(8):1333-46.
16. Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology 2018 Feb;154(3):689-703.
17. Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L, Kroemer G. Cell death modalities: classification and pathophysiological implications. Cell Death & Differentiation 2007 Jul;14(7):1237-43.
18. Gukovsky I, Pandol SJ, Gukovskaya AS. Organellar dysfunction in the pathogenesis of pancreatitis. Antioxidants & Redox Signaling 2011 Nov;15(10):2699-710.
19. Talukdar R, Sareen A, Zhu H, Yuan Z, Dixit A, Cheema H, George J, Barlass U, Sah R, Garg SK, Banerjee S, Garg P, Dudeja V, Dawra R, Saluja AK. Release of cathepsin B in cytosol causes cell death in acute pancreatitis. Gastroenterology 2016 Oct;151(4):747-58.e5.
20. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussinget J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. The Journal of Clinical Investigation 2000 Sep;106(6):773-81.
21. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008 Jan;132(1):27-42.
22. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008 Feb;451(7182):1069-75.
23. Ковалева О.В., Шитова М.С., Зборовская И.Б. Аутофагия: клеточная гибель или способ выживания? Клиническая онкогематология. Фундаментальные исследования и клиническая практика 2014;7(2):103-13.
24. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karina M. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proceedings of the National Academy of Sciences of the USA 2015 Nov;112(45):E6166-74.
25. Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition- dependent processes. Gastroenterology 2015 Mar;148(3):626-38.e17.
26. Mareninova OA, Hermann K, French SW, O’Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskayaet AS. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. The Journal of Clinical Investigation 2009 Nov;119(11):3340-55.
27. Wu JS, Li WM, Chen YN, Zhao Q, Chen QF. Endoplasmic reticulum stress is activated in acute pancreatitis. Journal of Digestive Diseases 2016 May;17(5):295-303.
28. Venglovecz V, Pallagi P, Kemény LV, Balázs A, Balla Z, Becskeházi E, Gál E, Tóth E, Zvara A, Puskás LG, Borka K, Sendler M, Lerch MM, Mayerle J, Kühn JP, Rakonczay Z Jr, Hegyi P. The importance of aquaporin 1 in pancreatitis and its relation to the CFTR Cl(-) channel. Frontiers in Physiology 2018;9:854.
29. Pallagi P, Hegyi P, Rakonczay ZJ. The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians. Pancreas 2015 Nov;44(8):1211-33.
30. Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z Jr, Maléth J. CFTR: a new horizon in the pathomechanism and treatment of pancreatitis. Reviews in Physiology, Biochemistry and Pharmacology 2016;170:37-66.
31. Hegyi P, Petersen OH. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Reviews of Physiology, Biochemistry and Pharmacology 2013;165:1-30.
32. Maleth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz A, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology 2015 Feb;148(2):427-39.e16.
33. Venglovecz V, Rakonczay Z Jr, Ozsvári B, Takács T, Lonovics J, Varró A, Gray MA, Argent BE, Hegyi P. Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig. Gut 2008 Aug;57(8):1102-12.
34. Jakkampudi A, Jangala R, Reddy R, Mitnala S, Rao GV, Pradeep R, Reddy DN, Talukdar R. Acinar injury and early cytokine response in human acute biliary pancreatitis. Scientific Reports 2017 Nov;7(1):15276.
35. Eppensteiner J, Davis RP, Barbas AS, Kwun J, Lee J. Immunothrombotic activity of damage-associated molecular patterns and extracellular vesicles in secondary organ failure induced by trauma and sterile insults. Frontiers in Immunology 2018 Feb;9:190.
36. Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002 Apr;122(4):974-84.
37. Sendler M, Dummer A, Weiss FU, Krüger B, Wartmann T, Scharffetter-Kochanek K, van Rooijen N, Malla SR, Aghdassi A, Halangk W, Lerch MM, Mayerle J. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut 2013 Mar;62(3):430-9.
38. Aoun E, Chen J, Reighard D, Gleeson FS, Whitcomb DC, Papachristou GI. Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta- analysis. Pancreatology 2009;9(6):777-85.
39. Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. The Journal of Clinical Investigation 2013 Mar;123(3):1019-31.
40. Deviere J, Le Moine O, Van Laethem JL, Eisendrath P, Ghilain A, Severs N, Cohard M. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography. Gastroenterology 2001 Feb;120(2):498-505.
41. Lee B, Zhao Q, Habtezion A. Immunology of pancreatitis and environmental factors. Current Opinion in Gastroenterology 2017 Sep;33(5):383-9.
42. Hutchins AP, Diez D, Miranda-Saavedra D. The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Briefings in Functional Genomics 2013 Nov;12(6):489-98.
43. Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ. The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis. The Journal of Physiology 2019 Jun;597(12):3085-105.
44. Javed MA, Wen L, Awais M, Latawiec D, Huang W, Chvanov M, Schaller S, Bordet T, Michaud M, Pruss R, Tepikin A, Criddle D, Sutton R. TRO40303 ameliorates alcohol-induced pancreatitis through reduction of fatty acid ethyl ester-induced mitochondrial injury and necrotic cell death. Pancreas 2018 Jan;47(1):18-24.
45. Atar D, Arheden H, Berdeaux A, Bonnet JL, Carlsson M, Clemmensen P, Cuvier V, Danchin N, Dubois-Randé JL, Engblom H, Erlinge D, Firat H, Halvorsen S, Hansen HS, Hauke W, Heiberg E, Koul S, Larsen AI, Le Corvoisier P, Nordrehaug JE, Paganelli F, Pruss RM, Rousseau H, Schaller S, Sonou G, Tuseth V, Veys J, Vicaut E, Jensen SE. Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results. European Heart Journal 2015 Jan;36(2):112-9.
46. Le Lamer S, Paradis S, Rahmouni H, Chaimbault C, Michaud M, Culcasi M, Afxantidis J, Latreille M, Berna P, Berdeaux A, Pietri S, Morin D, Donazzolo Y, Abitbol JL, Pruss RM, Schaller S. Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized phase I trial. Journal of Translational Medicine 2014 Feb;12:38.
47. Marta K, Szabó AN, Pécsi D, Varjú P, Bajor J, Gódi S, Sarlós P, Mikó A, Szemes K, Papp M, Tornai T, Vincze A, Márton Z, Vincze PA, Lankó E, Szentesi A, Molnár T, Hágendorn R, Faluhelyi N, Battyáni I, Kelemen D, Papp R, Miseta A, Verzár Z, Lerch MM, Neoptolemos JP, Sahin-Tóth M, Petersen OL, Hegyi P; Hungarian Pancreatic Study Group. High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial. BMJ Open 2017 Sep;7(9):e015874.
48. Lee HJ, Yoon YS, Lee SJ. Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction. Cell Death & Disease 2018 Jun;9(7):712.
49. Vege SS, Atwal T, Bi Y, Chari ST, Clemens MA, Enders FT. Pentoxifylline treatment in severe acute pancreatitis: a pilot, double-blind, placebo-controlled, randomized trial. Gastroenterology 2015 Aug;149(2):318-20.e3.
50. Chen KL, Lv ZY, Yang HW, Liu Y, Long FW, Zhou B, Sun XF, Peng ZH, Zhou ZG, Li Y. Effects of tocilizumab on experimental severe acute pancreatitis and associated acute lung injury. Critical Care Medicine 2016 Aug;44(4):e664-77.
51. Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, Brouwer E, Cid MC, Dasgupta B, Rech J, Salvarani C, Schett G, Schulze-Koops H, Spiera R, Unizony SH, Collinson N. Trial of tocilizumab in giant-cell arteritis. The New England Journal of Medicine 2017 Jul;377(4):317-28.
52. Schirmer M, Muratore F, Salvarani C. Tocilizumab for the treatment of giant cell arteritis. Expert Review of Clinical Immunology 2018 May;14(5):339-49.
53. Pablos JL, Navarro F, Blanco FJ, Román-Ivorra JA, Alonso A, Mola EM, Cantalejo M, Ercole L, Rivero N; Study Investigators. Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study. Clinical and Experimental Rheumatology 2019 May-Jun;37(3):437-44.

References

1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri IS, Gangarosa LM, Jensen ET, Lund JL, Pasricha S, Runge T, Schmidt M, Shaheen NJ, Sandler RS. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology 2015 Dec;149(7):1731-41.e3.
2. Wadhwa V, Patwardhan S, Gard SK, Jobanputra Y, Lopez R, Sanaka MR. Health care utilization and costs associated with acute pancreatitis. Pancreas 2017 Mar;46(3):410-5.
3. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nature Reviews. Gastroenterology & Hepatology 2019 Mar;16(3):175-84.
4. Krishna SG, Kamboj AK, Hart PA, Hinton A, Conwell DL. The changing epidemiology of acute pancreatitis hospitalizations: a decade of trends and the impact of chronic pancreatitis. Pancreas 2017 Apr;46(4):482-8.
5. Párniczky A, Kui B, Szentesi A, Balázs A, Szűcs A, Mosztbacher D, Czimmer J, Sarlós P, Bajor J, Gódi S, Vincze A, Illés A, Szabó I, Pár G, Takács T, Czakó L, Szepes Z, Rakonczay Z, Izbéki F, Gervain J, Halász A, Novák J, Crai S, Hritz I, Góg C, Sümegi J, Golovics P, Varga M, Bod B, Hamvas J, Varga-Müller M, Papp Z, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group. Prospective, multicentre, nationwide clinical data from 600 cases of acute pancreatitis. PLoS One 2016 Oct;11(10):e0165309.
6. Maléth J, Hegyi P. Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 2016 Aug;371(1700):20150425.
7. Krüger B, Albrecht E, Lerch MM. The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. The American Journal Pathology 2000 Jul;157(1):43-50.
8. Raraty M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, Petersen OH. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the USA 2000 Nov;97(24):13126-31.
9. Criddle DN, McLaughlin E, Murphy JA, Petersen OH, Sutton R. The pancreas misled: signals to pancreatitis. Pancreatology 2007;7(5-6):436-46.
10. Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 2005 Oct;437(7060):902-5.
11. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J, Begg M, Stauderman K, Roos J, Grigoryev S, Ramos S, Rogers E, Whitten J, Velicelebi G, Dunn M, Tepikin AV, Criddle DN, Sutton R. Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models. Gastroenterology 2015 Aug;149(2):481-92.e7.
12. Gukovskaya AS, Pandol SJ, Gukovsky I. New insights into the pathways initiating and driving pancreatitis. Current Opinion in Gastroenterology 2016 Sep;32(5):429-35.
13. Lur G, Sherwood MW, Ebisui E, Haynes L, Feske S, Sutton R, Burgoyne RD, Mikoshiba K, Petersen OH, Tepikin AV. InsP(3)receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. The Biochemical Journal 2011 Jun;436(2):231-9.
14. Romac JMJ, Shahid RA, Swain SM, Vigna SR, Liddle RA. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nature Communications 2018 Apr;9(1):1715.
15. Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R; NIHR Pancreas Biomedical Research Unit. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut 2016 Aug;65(8):1333-46.
16. Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology 2018 Feb;154(3):689-703.
17. Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L, Kroemer G. Cell death modalities: classification and pathophysiological implications. Cell Death & Differentiation 2007 Jul;14(7):1237-43.
18. Gukovsky I, Pandol SJ, Gukovskaya AS. Organellar dysfunction in the pathogenesis of pancreatitis. Antioxidants & Redox Signaling 2011 Nov;15(10):2699-710.
19. Talukdar R, Sareen A, Zhu H, Yuan Z, Dixit A, Cheema H, George J, Barlass U, Sah R, Garg SK, Banerjee S, Garg P, Dudeja V, Dawra R, Saluja AK. Release of cathepsin B in cytosol causes cell death in acute pancreatitis. Gastroenterology 2016 Oct;151(4):747-58.e5.
20. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussinget J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. The Journal of Clinical Investigation 2000 Sep;106(6):773-81.
21. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008 Jan;132(1):27-42.
22. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008 Feb;451(7182):1069-75.
23. Kovaleva OV, Shitova MS, Zborovskaya IB. Autophagy: cell death or survival strategy? Clinical Oncohematology. Basic Research and Clinical Practice 2014;7(2):103-13 (In Russian).
24. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karina M. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proceedings of the National Academy of Sciences of the USA 2015 Nov;112(45):E6166-74.
25. Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition- dependent processes. Gastroenterology 2015 Mar;148(3):626-38.e17.
26. Mareninova OA, Hermann K, French SW, O’Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskayaet AS. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. The Journal of Clinical Investigation 2009 Nov;119(11):3340-55.
27. Wu JS, Li WM, Chen YN, Zhao Q, Chen QF. Endoplasmic reticulum stress is activated in acute pancreatitis. Journal of Digestive Diseases 2016 May;17(5):295-303.
28. Venglovecz V, Pallagi P, Kemény LV, Balázs A, Balla Z, Becskeházi E, Gál E, Tóth E, Zvara A, Puskás LG, Borka K, Sendler M, Lerch MM, Mayerle J, Kühn JP, Rakonczay Z Jr, Hegyi P. The importance of aquaporin 1 in pancreatitis and its relation to the CFTR Cl(-) channel. Frontiers in Physiology 2018;9:854.
29. Pallagi P, Hegyi P, Rakonczay ZJ. The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians. Pancreas 2015 Nov;44(8):1211-33.
30. Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z Jr, Maléth J. CFTR: a new horizon in the pathomechanism and treatment of pancreatitis. Reviews in Physiology, Biochemistry and Pharmacology 2016;170:37-66.
31. Hegyi P, Petersen OH. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Reviews of Physiology, Biochemistry and Pharmacology 2013;165:1-30.
32. Maleth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz A, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology 2015 Feb;148(2):427-39.e16.
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